Search Ontology:
ChEBI
epalrestat
- Term ID
- CHEBI:31539
- Synonyms
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- 5-((1Z,2E)-2-methyl-3-phenylpropenylidene)-4-oxo-2-thioxo-3-thiazolidineacetic acid
- 5-((Z,E)-beta-methylcinnamylidene)-4-oxo-2-thioxo-3-thiazolidineacetic acid
- epalrestat
- epalrestatum
- Kinedak
- ONO 2
- Ono 2235
- ONO-2
- ONO-2235
- {(5Z)-5-[(2E)-2-methyl-3-phenylprop-2-en-1-ylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl}acetic acid
- Definition
- A monocarboxylic acid that is 1,3-thiazolidine which is substituted on the nitrogen by a carboxymethyl group, at positions 2 and 4 by thioxo and oxo groups, respectively, and at position 5 by a 2-methyl-3-phenylprop-2-en-1-ylidene group. It is an inhibitor of aldose reductase (which catalyses the conversion of glucose to sorbitol) and is used for the treatment of some diabetic complications, including neuropathy.
- References
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- CAS:82159-09-9
- Drug_Central:1021
- KEGG:D01688
- PDBeChem:EPR
- PMID:19716319
- PMID:22820572
- PMID:23426701
- PMID:24363998
- PMID:3025043
- Patent:EP47109
- Patent:US4464382
- Reaxys:4236712
- Wikipedia:Epalrestat
- Ontology
- ChEBI ( EBI )
- Resources
- CTD
- is a type of
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- has_role
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Phenotype
Phenotype resulting from epalrestat
Phenotype where environments contain epalrestat
Phenotype modified by environments containing epalrestat
Human Disease / Model Data