Search Ontology:
ChEBI

epalrestat

Term ID
CHEBI:31539
Synonyms
  • 5-((1Z,2E)-2-methyl-3-phenylpropenylidene)-4-oxo-2-thioxo-3-thiazolidineacetic acid
  • 5-((Z,E)-beta-methylcinnamylidene)-4-oxo-2-thioxo-3-thiazolidineacetic acid
  • epalrestat
  • epalrestatum
  • Kinedak
  • ONO 2
  • Ono 2235
  • ONO-2
  • ONO-2235
  • {(5Z)-5-[(2E)-2-methyl-3-phenylprop-2-en-1-ylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl}acetic acid
Definition
A monocarboxylic acid that is 1,3-thiazolidine which is substituted on the nitrogen by a carboxymethyl group, at positions 2 and 4 by thioxo and oxo groups, respectively, and at position 5 by a 2-methyl-3-phenylprop-2-en-1-ylidene group. It is an inhibitor of aldose reductase (which catalyses the conversion of glucose to sorbitol) and is used for the treatment of some diabetic complications, including neuropathy.
References
Ontology
ChEBI  ( EBI )
Resources
CTD
Relationships
is a type of
has_role
Phenotype
Phenotype resulting from epalrestat
Phenotype where environments contain epalrestat
Phenotype modified by environments containing epalrestat
Human Disease Model