acadesine

Term ID

CHEBI:28498

Synonyms

5-amino-1-(beta-D-ribofuranosyl)-1H-imidazole-4-carboxamide
5-amino-1-beta-D-ribofuranosyl-4-imidazolecarboxamide
5-amino-1-beta-D-ribofuranosylimidazole-4-carboxamide
5-amino-1-beta-ribofuranosyl-imidazole-4-carboxamide
5-amino-1-ribofuranosylimidazole-4-carboxamide
5-amino-1beta-D-ribofuranosylimidazole-4-carboxyamide
5-amino-4-imidazolecarboxamide ribofuranoside
5-aminoimidazole-4-carboxamide ribonucleoside
acadesina
acadesine
acadesinum
AIC-Riboside
AICA-riboside
AICAr
EC Number 220-097-5
GP 1-110
GP-1-110
N(1)-(beta-D-ribofuranosyl)-5-aminoimidazole-4-carboxamide

Definition

A 1-ribosylimidazolecarboxamide in which the carboxamide group is situated at position 4 of the imidazole ring, which is further substituted at position 5 by an amino group. A purine nucleoside analogue and activator of AMP-activated protein kinase, it is is used for the treatment of acute lymphoblastic leukemia and is reported to have cardioprotective effects.

References

Ontology

ChEBI ( EBI )

Resources

CTD

Relationships

is a type of: 1-ribosylimidazolecarboxamide aminoimidazole nucleoside analogue

1-ribosylimidazolecarboxamide aminoimidazole nucleoside analogue Show first 5 Terms
has_role: antineoplastic agent platelet aggregation inhibitor

antineoplastic agent platelet aggregation inhibitor Show first 5 Terms
inverse has_functional_parent: AICA ribonucleotide

AICA ribonucleotide Show first 5 Terms

Phenotype

Phenotype resulting from acadesine

Phenotype where environments contain acadesine

Phenotype modified by environments containing acadesine

Human Disease Model