SB-743921

Term ID

CHEBI:231716

Synonyms

GSK 743921
GSK-743921
GSK-921
GSK743921
N-(3-aminopropyl)-N-[(1R)-1-(3-benzyl-7-chloro-4-oxo-4H-chromen-2-yl)-2-methylpropyl]-4-methylbenzamide
N-(3-aminopropyl)-N-[(1R)-1-(3-benzyl-7-chloro-4-oxochromen-2-yl)-2-methylpropyl]-4-methylbenzamide
SB 743921
SB-743921 free base
SB-921
SB743921

Definition

A chromone that is 4H-chromen-4-one substituted by (1R)-1-[(3-aminopropyl)(4-methylbenzoyl)amino]-2-methylpropyl, benzyl, and chloro groups at positions 2, 3, and 7, respectively. It is a potent inhibitor of kinesin spindle protein (Ki = 0.1 nM) and exhibits antineoplastic activity.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: benzamides benzenes chromones organochlorine compound primary amino compound ... Show All 7 Terms

benzamides benzenes chromones organochlorine compound primary amino compound tertiary carboxamide toluenes Show first 5 Terms
has_role: antineoplastic agent apoptosis inducer microtubule-destabilising agent

antineoplastic agent apoptosis inducer microtubule-destabilising agent Show first 5 Terms

Phenotype

Phenotype resulting from SB-743921

Phenotype where environments contain SB-743921

Phenotype modified by environments containing SB-743921

Human Disease Model