Search Ontology:
ChEBI
vosaroxin
- Term ID
- CHEBI:231651
- Synonyms
-
- (+)-1,4-dihydro-7-(trans-3-methoxy-4-methylamino-1-pyrrolidinyl)-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid
- 7-[(3S,4S)-3-methoxy-4-(methylamino)pyrrolidin-1-yl]-4-oxo-1-(1,3-thiazol-2-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
- AG 7352
- AG-7352
- AG7352
- SNS 595
- SNS-595
- SPC-595
- voreloxin
- vosaroxin
- vosaroxina
- vosaroxine
- vosaroxinum
- Definition
- A 1,8-naphthyridine derivative that is 1,8-naphthyridin-4(1H)-one substituted by 1,3-thiazol-2-yl, carboxy, and (3S,4S)-3-methoxy-4-(methylamino)pyrrolidin-1-yl groups at positions 1, 3, and 7, respectively. It targets topoisomerase II and induces site-selective double-strand breaks in DNA, leading to apoptosis in cancer cells.
- References
-
- CAS:175414-77-4
- DrugBank:DB11999
- KEGG:D08024
- PMID:15056007
- PMID:18931998
- PMID:19074528
- PMID:20419121
- PMID:22369205
- PMID:22724917
- PMID:23688047
- PMID:25381131
- PMID:25403830
- PMID:25534904
- PMID:25805811
- PMID:25958926
- PMID:26234173
- PMID:27158854
- PMID:27236532
- PMID:27484675
- PMID:27615555
- PMID:28138829
- PMID:28415741
- PMID:28504025
- PMID:28567238
- PMID:28729302
- PMID:28860803
- PMID:29794146
- PMID:29800573
- PMID:30396931
- PMID:31115744
- PMID:31482470
- Patent:US2011312988
- Wikipedia:Vosaroxin
- Ontology
- ChEBI ( EBI )
- is a type of
- has_role
-
Show All 8 Terms
Show first 5 Terms
Phenotype
Phenotype resulting from vosaroxin
Phenotype where environments contain vosaroxin
Phenotype modified by environments containing vosaroxin
Human Disease Model