Search Ontology:
ChEBI

varlitinib

Term ID
CHEBI:231356
Synonyms
  • AR-00334543
  • AR00334543
  • ARRY 334543
  • ARRY-334543
  • ARRY-543
  • ASLAN-001
  • ASLAN001
  • N(4)-[3-chloro-4-(1,3-thiazol-2-ylmethoxy)phenyl]-N(6)-[(4R)-4-methyl-4,5-dihydro-1,3-oxazol-2-yl]quinazoline-4,6-diamine
  • varlitinib
  • varlitinibum
Definition
A member of the class of quinazolines that is quinazoline substituted by {3-chloro-4-[(1,3-thiazol-2-yl)methoxy]phenyl}amino and [(4R)-4-methyl-4,5-dihydro-1,3-oxazol-2-yl]amino groups at positions 4 and 6, respectively. It is a tyrosine kinase inhibitor of both ErbB-2 (Her-2/neu) and EGFR and has shown significant anti-tumour activity in preclinical models of human breast, lung, and epidermal carcinoma tumours.
References
Ontology
ChEBI  ( EBI )
Relationships
is a type of
has_role
Phenotype
Phenotype resulting from varlitinib
Phenotype where environments contain varlitinib
Phenotype modified by environments containing varlitinib
Human Disease Model
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