Search Ontology:
ChEBI
orteronel
- Term ID
- CHEBI:231353
- Synonyms
-
- (+)-orteronel
- (S)-orteronel
- 6-[(7S)-7-hydroxy-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-7-yl]-N-methylnaphthalene-2-carboxamide
- orteronel
- orteronelum
- TAK 700
- TAK-700
- TAK700
- Definition
- A member of the class of pyrroloimidazoles that is 6,7-dihydro-5H-pyrrolo[1,2-c]imidazole substituted by hydroxy and 6-(methylcarbamoyl)naphthalen-2-yl groups at position 7 (the 7S-stereoisomer). It is a non-steroidal 17,20-lyase inhibitor that suppresses androgen synthesis. It was previously in clinical development for the treatment of castration-resistant prostate cancer -- trial now discontinued.
- References
-
- CAS:566939-85-3
- DrugBank:DB12066
- KEGG:D10146
- PDBeChem:7D6
- PMCID:PMC4185570
- PMCID:PMC4218005
- PMID:21978946
- PMID:22249003
- PMID:22714983
- PMID:22793031
- PMID:23146910
- PMID:23788266
- PMID:23856460
- PMID:24418642
- PMID:24965748
- PMID:25556680
- PMID:25624429
- PMID:26382777
- PMID:26418412
- PMID:27046420
- PMID:27163496
- PMID:27163497
- PMID:27482286
- PMID:28373265
- PMID:28427507
- PMID:31072872
- PMID:32223238
- PMID:34273352
- PMID:34824002
- PMID:35250590
- PMID:35446628
- PMID:37085425
- PMID:37745904
- PMID:38424319
- PMID:38523017
- Wikipedia:Orteronel
- Ontology
- ChEBI ( EBI )
- is a type of
-
- has_role
-
Phenotype
Phenotype resulting from orteronel
Phenotype where environments contain orteronel
Phenotype modified by environments containing orteronel
Human Disease / Model Data