PLS-123

Term ID

CHEBI:230531

Synonyms

2-methyl-N-[2-(3-{[N-(prop-2-enoyl)glycyl]amino}anilino)pyrimidin-5-yl]-5-[3-(trifluoromethyl)benzamido]benzamide
N-(2-((3-(2-acrylamidoacetamido)phenyl)amino)pyrimidin-5-yl)-2-methyl-5-(3-(trifluoromethyl)benzamido)benzamide
PLS 123
PLS123

Definition

A member of the class of pyrimidines that is pyrimidine substituted by (3-{[N-(prop-2-enoyl)glycyl]amino}phenyl)amino and {2-methyl-5-[3-(trifluoromethyl)benzamido]benzoyl}nitrilo groups at positions 2 and 5, respectively. It is a covalent BTK inhibitor with potential anti-proliferative activity. It exhibits more potent anti-proliferative effects than ibrutinib in multiple cellular and in vivo preclinical models of B-cell lineage malignancy, including tumor cell lines and mouse xenograft models.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: (trifluoromethyl)benzenes acrylamides aminopyrimidine benzamides secondary amino compound ... Show All 7 Terms

(trifluoromethyl)benzenes acrylamides aminopyrimidine benzamides secondary amino compound secondary carboxamide toluenes Show first 5 Terms
has_role: antineoplastic agent apoptosis inducer EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor

antineoplastic agent apoptosis inducer EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor Show first 5 Terms

Phenotype

Phenotype resulting from PLS-123

Phenotype where environments contain PLS-123

Phenotype modified by environments containing PLS-123

Human Disease Model