iptacopan

Term ID

CHEBI:229652

Synonyms

4-{(2S,4S)-4-ethoxy-1-[(5-methoxy-7-methyl-1H-indol-4-yl)methyl]piperidin-2-yl}benzoic acid
iptacopan
iptacopanum
LNP 023
LNP-023
LNP023
NVP-LNP023

Definition

A member of the class of indoles that is 1H-indole substituted by [(2S,4S)-2-(4-carboxyphenyl)-4-ethoxypiperidin-1-yl]methyl, methoxy, and methyl groups at positions 4, 5, and 6, respectively. It is a potent inhibitor of complement factor B (IC50 = 10nM) with potential immunomodulatory activity.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: benzoic acids diether ether indoles monocarboxylic acid ... Show All 7 Terms

benzoic acids diether ether indoles monocarboxylic acid piperidines tertiary amino compound Show first 5 Terms
has_role: complement factor B inhibitor immunomodulator

complement factor B inhibitor immunomodulator Show first 5 Terms
inverse is_conjugate_acid_of: iptacopan(1+)

iptacopan(1+) Show first 5 Terms
is_conjugate_base_of: iptacopan(1+)

iptacopan(1+) Show first 5 Terms

Phenotype

Phenotype resulting from iptacopan

Phenotype where environments contain iptacopan

Phenotype modified by environments containing iptacopan

Human Disease / Model Data