Search Ontology:
ChEBI
entrectinib
- Term ID
- CHEBI:195558
- Synonyms
-
- entrectinib
- entrectinibum
- N-[5-(3,5-difluorobenzyl)-1H-indazol-3-yl]-4-(4-methylpiperazin-1-yl)-2-(tetrahydro-2H-pyran-4-ylamino)benzamide
- N-[5-[(3,5-difluorophenyl)methyl]-1H-indazol-3-yl]-4-(4-methyl-1-piperazinyl)-2-[(tetrahydro-2H-pyran-4-yl)amino]benzamide
- N-[5-[[3,5-bis(fluoranyl)phenyl]methyl]-1H-indazol-3-yl]-4-(4-methylpiperazin-1-yl)-2-(oxan-4-ylamino)benzamide
- NMS-E 628
- NMS-E628
- RG 6268
- RG-6268
- RG6268
- Rozlytrek
- RXDX 101
- RXDX-101
- Definition
- A member of the class of indazoles that is 1H-indazole substituted by [4-(4-methylpiperazin-1-yl)-2-(tetrahydro-2H-pyran-4-ylamino)benzoyl]amino and 3,5-difluorobenzyl groups at positions 3 and 5, respectively. It is a potent inhibitor of TRKA, TRKB, TRKC, ROS1, and ALK (IC50 values of 0.1 to 1.7 nM), and used for the treatment of NTRK, ROS1 and ALK gene fusion-positive solid tumours.
- References
-
- CAS:1108743-60-7
- Chemspider:24808589
- DrugBank:DB11986
- HMDB:HMDB0304880
- KEGG:D10926
- PDBeChem:YMX
- PMID:26633560
- PMID:27003761
- PMID:32907817
- PMID:33290717
- PMID:34209967
- PMID:34253025
- PMID:34536094
- PMID:34633782
- PMID:35118559
- PMID:35447552
- PMID:35663414
- PMID:35775007
- PMID:36101520
- PMID:36106272
- PMID:36229359
- PMID:36340796
- PMID:36375321
- PMID:36378538
- PMID:36419889
- PMID:36605067
- PMID:36699581
- PMID:36703785
- PMID:36884068
- PMID:36921521
- PMID:36924196
- PMID:37062732
- PMID:37086377
- PMID:37122438
- PMID:37287496
- PMID:37393426
- PMID:37492244
- PMID:37544307
- Wikipedia:Entrectinib
- Ontology
- ChEBI ( EBI )
- is a type of
- has_role
-
Show All 7 Terms
Show first 5 Terms
Phenotype
Phenotype resulting from entrectinib
Phenotype where environments contain entrectinib
Phenotype modified by environments containing entrectinib
Human Disease Model