JTE-013

Term ID

CHEBI:195541

Synonyms

1-(2,6-dichloro-4-pyridinyl)-3-[(1,3-dimethyl-4-propan-2-yl-6-pyrazolo[3,4-b]pyridinyl)amino]urea
1-[1,3-dimethyl-4-(2-methylethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]-4-(2,6-dichloro-4-pyridinyl)-semicarbazide
JTE 013
JTE013
N-(2,6-dichloropyridin-4-yl)-2-[1,3-dimethyl-4-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridin-6-yl]hydrazine-1-carboxamide
N-(2,6-dichloropyridin-4-yl)-2-[1,3-dimethyl-4-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridin-6-yl]hydrazinecarboxamide

Definition

A semicarbazide derivative that is semicarbazide in which the amino group at position 2 is replaced by a [1,3-dimethyl-4-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridin-6-yl]amino group and the amino group adjacent to the carbonyl is replaced by a (2,6-dichloropyridin-4-yl)amino group. It is a potent S1P2 antagonist (IC50 = 17.6 nM).

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: chloropyridine pyrazolopyridine

chloropyridine pyrazolopyridine Show first 5 Terms
has_functional_parent: semicarbazide

semicarbazide Show first 5 Terms
has_role: anti-asthmatic agent anti-inflammatory agent antineoplastic agent osteogenesis regulator pro-angiogenic agent ... Show All 6 Terms

anti-asthmatic agent anti-inflammatory agent antineoplastic agent osteogenesis regulator pro-angiogenic agent sphingosine-1-phosphate receptor 2 antagonist Show first 5 Terms

Phenotype

Phenotype resulting from JTE-013

Phenotype where environments contain JTE-013

Phenotype modified by environments containing JTE-013

Human Disease Model