Search Ontology:
ChEBI
SU11274
- Term ID
- CHEBI:190974
- Synonyms
-
- (3Z)-N-(3-chlorophenyl)-3-({3,5-dimethyl-4-[(4-methylpiperazin-1-yl)carbonyl]-1H-pyrrol-2-yl}methylidene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide
- PKI-SU11274
- SU 11274
- SU-11274
- Definition
- A member of the class of oxindoles that is 1,3-dihydro-2H-indol-2-one substituted by {3,5-dimethyl-4-[(4-methylpiperazin-1-yl)carbonyl]-1H-pyrrol-2-yl}methylidene and N-(3-chlorophenyl)-N-methylmethanesulfonyl groups at positions 3 and 5, respectively. It is a potent ATP-competitive inhibitor of c-Met (IC50 = 20 nM) and exhibits antineoplastic activity.
- References
-
- CAS:658084-23-2
- Chemspider:7828213
- LINCS:LSM-42792
- PDBeChem:274
- PMID:15064724
- PMID:15735036
- PMID:18021219
- PMID:18239682
- PMID:19238632
- PMID:19783361
- PMID:20370683
- PMID:21572247
- PMID:21575221
- PMID:22466960
- PMID:22673163
- PMID:23026049
- PMID:23360489
- PMID:23527257
- PMID:23536000
- PMID:23566349
- PMID:23876900
- PMID:25279148
- PMID:26622692
- PMID:26790028
- PMID:27175734
- PMID:28835699
- PMID:29752941
- PMID:30233210
- PMID:32428505
- PMID:32686903
- PMID:33227394
- PMID:33344167
- PMID:34257586
- PMID:35760785
- PMID:38273381
- PMID:38442547
- PMID:38766346
- PMID:38820210
- Ontology
- ChEBI ( EBI )
- is a type of
- has_role
-
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Phenotype
Phenotype resulting from SU11274
Phenotype where environments contain SU11274
Phenotype modified by environments containing SU11274
Human Disease / Model Data