Search Ontology:
ChEBI

SYC-435

Term ID
CHEBI:189826
Synonyms
  • 1-hydroxy-4-methyl-6-(phenylmethyl)-2-(1H)pyridinone
  • 1-hydroxy-4-methyl-6-benzyl-2(1H)-pyridone
  • 6-benzyl-1-hydroxy-4-methyl-1,2-dihydropyridin-2-one
  • 6-benzyl-1-hydroxy-4-methylpyridin-2(1H)-one
  • 6-benzyl-1-hydroxy-4-methylpyridin-2-one
  • 6-benzyl-4-methyl-1-hydroxypyridin-2(1H)-one
  • SYC 435
  • SYC435
  • TC-E 5008
Definition
A cyclic hydroxamic acid that is 1-hydroxypyridin-2(1H)-one in which the hydrogens at positions 4 and 6 are substituted by methyl and benzyl groups, respectively. It is a potent inhibitor of mutant isocitrate dehydrogenase 1 (Ki values of 190 nM against R132H mutant and 120 nM against R132C mutant).
References
Ontology
ChEBI  ( EBI )
Relationships
is a type of
has_role
Phenotype
Phenotype resulting from SYC-435
Phenotype where environments contain SYC-435
Phenotype modified by environments containing SYC-435
Human Disease Model
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