ManNAz-DBCO-Pam3CSK4

Term ID

CHEBI:183049

Synonyms

• 5-{[8-(3-{[(2R)-6-amino-2-{[(2R)-6-amino-2-{[(2R)-6-amino-2-({S-[2,3-bis(hexadecanoyloxy)propyl]-N-hexadecanoyl-D-cysteinyl-D-seryl-D-lysyl}amino)hexanoyl]amino}hexanoyl]amino}hexanoyl]amino}propanoyl)-3a,8,9,13b-tetrahydro-3H-dibenzo[b,f][1,2,3]triazolo[

Definition

A carbohydrate derivative formed from a tetra-acetyl-N-azidoacetylmannosamine (AC4ManNAz) linked through a dibenzylcyclooctyl group (DBCO) to the triacylipopeptide N-palmitoyl-S-[2,3-bis(palmitoyloxy)propyl]-Cys-Ser-Lys-Lys-Lys-Lys (Pam3CSK4; CHEBI:134411). Commonly abbreviated to MDP, it has been developed as an artificial neoantigen on tumour cells to enhance tumour immunogenicity, able to significantly improve the response and the clinical outcome of immune checkpoint inhibitors (ICIs).

References

• PMID:34158858

Ontology

ChEBI  ( EBI )