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ChEBI

ManNAz-DBCO-Pam3CSK4

Term ID
CHEBI:183049
Synonyms
  • 5-{[8-(3-{[(2R)-6-amino-2-{[(2R)-6-amino-2-{[(2R)-6-amino-2-({S-[2,3-bis(hexadecanoyloxy)propyl]-N-hexadecanoyl-D-cysteinyl-D-seryl-D-lysyl}amino)hexanoyl]amino}hexanoyl]amino}hexanoyl]amino}propanoyl)-3a,8,9,13b-tetrahydro-3H-dibenzo[b,f][1,2,3]triazolo[
Definition
A carbohydrate derivative formed from a tetra-acetyl-N-azidoacetylmannosamine (AC4ManNAz) linked through a dibenzylcyclooctyl group (DBCO) to the triacylipopeptide N-palmitoyl-S-[2,3-bis(palmitoyloxy)propyl]-Cys-Ser-Lys-Lys-Lys-Lys (Pam3CSK4; CHEBI:134411). Commonly abbreviated to MDP, it has been developed as an artificial neoantigen on tumour cells to enhance tumour immunogenicity, able to significantly improve the response and the clinical outcome of immune checkpoint inhibitors (ICIs).
References
Ontology
ChEBI  ( EBI )
Relationships
is a type of
has_role
Phenotype
Phenotype resulting from ManNAz-DBCO-Pam3CSK4
Phenotype where environments contain ManNAz-DBCO-Pam3CSK4
Phenotype modified by environments containing ManNAz-DBCO-Pam3CSK4
Human Disease / Model Data