Search Ontology:
ChEBI

plinabulin

Term ID
CHEBI:177413
Synonyms
  • (3Z,6Z)-3-benzylidene-6-[(5-tert-butyl-1H-imidazol-4-yl)methylidene]piperazine-2,5-dione
  • BPI 2358
  • BPI-2358
  • NPI 2358
  • NPI-2358
  • NPI2358
  • plinabulin
  • plinabulina
  • plinabuline
  • plinabulinum
Definition
A member of the class of 2,5-diketopiperazines that is piperazine-2,5-dione substituted by benzylidene and (5-tert-butyl-1H-imidazol-4-yl)methylidene groups at positions 3 and 6, respectively. It is a vascular disrupting agent and a microtubule destabalising agent which was in clinical trials (now discontinued) for the treatment of non-small cell lung cancer.
References
Ontology
ChEBI  ( EBI )
Relationships
is a type of
has_role
Phenotype
Phenotype resulting from plinabulin
Phenotype where environments contain plinabulin
Phenotype modified by environments containing plinabulin
Human Disease Model
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