naxagolide

Term ID

CHEBI:177372

Synonyms

(+)-4-propyl-9-hydroxynaphthoxazine
(+)-PHNO
(4aR,10bR)-4-propyl-3,4,4a,5,6,10b-hexahydro-2H-naphtho[1,2-b][1,4]oxazin-9-ol
(4aR-trans)-3,4,4a,5,6,10b-hexahydro-4-propyl-2H-naphth[1,2-b]-1,4-oxazin-9-ol
dopazinol
naxagolida
naxagolide
naxagolidum
nazagolide
PHNO

Definition

An organic heterotricyclic compound that is (4aR,10bR)-3,4,4a,5,6,10b-hexahydro-2H-naphtho[1,2-b][1,4]oxazine substituted by propyl and hydroxy groups at positions 4 and 9, respectively. It is a potent dopamine D2-receptor agonist and its hydrochloride salt was under clinical development by Merck & Co as a potential antiparkinsonian agent (now discontinued).

References

Ontology

ChEBI ( EBI )

Resources

CTD

Relationships

is a type of: organic heterotricyclic compound phenols tertiary amino compound

organic heterotricyclic compound phenols tertiary amino compound Show first 5 Terms
has_role: anticonvulsant antiparkinson drug dopamine agonist

anticonvulsant antiparkinson drug dopamine agonist Show first 5 Terms
inverse is_conjugate_acid_of: naxagolide(1+)

naxagolide(1+) Show first 5 Terms
is_conjugate_base_of: naxagolide(1+)

naxagolide(1+) Show first 5 Terms

Phenotype

Phenotype resulting from naxagolide

Phenotype where environments contain naxagolide

Phenotype modified by environments containing naxagolide

Human Disease Model