Search Ontology:
ChEBI

niraparib

Term ID
CHEBI:176844
Synonyms
  • 2-[4-(3S)-3-piperidinylphenyl]-2H-indazole-7-carboxamide
  • 2-[4-[(3S)-piperidin-3-yl]phenyl]indazole-7-carboxamide
  • 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide
  • MK 4827
  • MK-4827
  • MK4827
  • niraparib
  • niraparibum
  • Zejula
Definition
A 2-[4-(piperidin-3-yl)phenyl]-2H-indazole-7-carboxamide that has S-configuration. It is a potent inhibitor of PARP1 and PARP2 (IC50 of 3.8 and 2.1 nM, respectively) and approved as a first-line maintenance treatment for women with advanced ovarian cancer after responding to platinum-based chemotherapy.
References
Ontology
ChEBI  ( EBI )
Relationships
is a type of
has_role
Phenotype
Phenotype resulting from niraparib
Phenotype where environments contain niraparib
Phenotype modified by environments containing niraparib
Human Disease / Model Data
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