Search Ontology:
ChEBI
niraparib
- Term ID
- CHEBI:176844
- Synonyms
-
- 2-[4-(3S)-3-piperidinylphenyl]-2H-indazole-7-carboxamide
- 2-[4-[(3S)-piperidin-3-yl]phenyl]indazole-7-carboxamide
- 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide
- MK 4827
- MK-4827
- MK4827
- niraparib
- niraparibum
- Zejula
- Definition
- A 2-[4-(piperidin-3-yl)phenyl]-2H-indazole-7-carboxamide that has S-configuration. It is a potent inhibitor of PARP1 and PARP2 (IC50 of 3.8 and 2.1 nM, respectively) and approved as a first-line maintenance treatment for women with advanced ovarian cancer after responding to platinum-based chemotherapy.
- References
-
- CAS:1038915-60-4
- Chemspider:24531930
- DrugBank:DB11793
- Drug_Central:5222
- KEGG:D10140
- PDBeChem:3JD
- PMID:19873981
- PMID:23482742
- PMID:24970803
- PMID:28001384
- PMID:29081841
- PMID:29214031
- PMID:29856239
- PMID:30096696
- PMID:31857852
- PMID:32073931
- PMID:32679152
- PMID:32753559
- PMID:32863940
- PMID:33361107
- PMID:33407715
- PMID:33470063
- PMID:33545804
- PMID:33559417
- PMID:33621324
- PMID:33641880
- PMID:33691564
- PMID:33774805
- PMID:33905671
- PMID:33915252
- PMID:33920140
- PMID:33993885
- PMID:34073147
- PMID:34164503
- PMID:34241562
- PMID:34307148
- PMID:34324028
- PMID:34327724
- Patent:KR20100114021
- Wikipedia:Niraparib
- Ontology
- ChEBI ( EBI )
- is a type of
-
- has_role
-
Show first 5 Terms
Phenotype
Phenotype resulting from niraparib
Phenotype where environments contain niraparib
Phenotype modified by environments containing niraparib
Human Disease Model