PJ34

Term ID

CHEBI:167900

Synonyms

2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamide
2-(dimethylaminoacetylamino)-5,6-dihydrophenanthridine-6-one
N(2),N(2)-dimethyl-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)glycinamide
N-(5,6-dihydro-6-oxo-2-phenanthridinyl)-2-(dimethylamino)acetamide
N-(5,6-dihydro-6-oxophenanthridine-2-yl)-2-(dimethylamino)acetamide
PJ 34
PJ-34

Definition

A member of the class of phenanthridines that is 5,6-dihydrophenanthridine substituted at positions 2 and 6 by (N,N-dimethylglycyl)amino and oxo groups, respectively. It is a potent inhibitor of poly(ADP-ribose) polymerases PARP1 and PARP2 (IC50 of 110 nM and 86 nM, respectively) and exhibits anti-cancer, cardioprotective and neuroprotective properties.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: phenanthridines secondary carboxamide tertiary amino compound

phenanthridines secondary carboxamide tertiary amino compound Show first 5 Terms
has_role: angiogenesis inhibitor anti-inflammatory agent antiatherosclerotic agent antineoplastic agent apoptosis inducer ... Show All 8 Terms

angiogenesis inhibitor anti-inflammatory agent antiatherosclerotic agent antineoplastic agent apoptosis inducer cardioprotective agent EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor neuroprotective agent Show first 5 Terms
inverse is_conjugate_acid_of: PJ34(1+)

PJ34(1+) Show first 5 Terms
is_conjugate_base_of: PJ34(1+)

PJ34(1+) Show first 5 Terms

Phenotype

Phenotype resulting from PJ34

Phenotype where environments contain PJ34

Phenotype modified by environments containing PJ34

Human Disease Model