TAK-632

Term ID

CHEBI:167673

Synonyms

N-(7-cyano-6-(4-fluoro-3-(2-(3-(trifluoromethyl)phenyl)acetamido)phenoxy)benzo[d]thiazol-2-yl)cyclopropanecarboxamide
N-[5-[[7-cyano-2-[(cyclopropylcarbonyl)amino]-6-benzothiazolyl]oxy]-2-fluorophenyl]-3-(trifluoromethyl)-benzeneacetamide
N-[7-cyano-6-(4-fluoro-3-{2-[3-(trifluoromethyl)phenyl]acetamido}phenoxy)-1,3-benzothiazol-2-yl]cyclopropanecarboxamide
TAK 632
TAK632

Definition

A member of the class of benzothiazoles that is 1,3-benzothiazole substituted by (cyclopropanecarbonyl)amino, 4-fluoro-3-{2-[3-(trifluoromethyl)phenyl]acetamido}phenoxy, and cyano groups at positions 2, 6 and 7, respectively. It is a potent pan-RAF inhibitor with IC50 of 1.4, 2.4 and 8.3 nM for CRAF, BRAF(V600E), BRAF(WT), respectively.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: (trifluoromethyl)benzenes aromatic ether benzothiazoles cyclopropylcarboxamide monofluorobenzenes ... Show All 7 Terms

(trifluoromethyl)benzenes aromatic ether benzothiazoles cyclopropylcarboxamide monofluorobenzenes nitrile secondary carboxamide Show first 5 Terms
has_role: antineoplastic agent apoptosis inducer B-Raf inhibitor EC 2.7.11.26 (tau-protein kinase) inhibitor necroptosis inhibitor

antineoplastic agent apoptosis inducer B-Raf inhibitor EC 2.7.11.26 (tau-protein kinase) inhibitor necroptosis inhibitor Show first 5 Terms

Phenotype

Phenotype resulting from TAK-632

Phenotype where environments contain TAK-632

Phenotype modified by environments containing TAK-632

Human Disease Model