TAK-580

Term ID

CHEBI:167672

Synonyms

• 2-[(1R)-1-[(6-amino-5-chloropyrimidine-4-carbonyl)amino]ethyl]-N-[5-chloro-4-(trifluoromethyl)pyridin-2-yl]-1,3-thiazole-5-carboxamide
• 6-amino-5-chloro-N-[(1R)-1-(5-{[5-chloro-4-(trifluoromethyl)pyridin-2-yl]carbamoyl}-1,3-thiazol-2-yl)ethyl]pyrimidine-4-carboxamide
• AMG 2112819
• AMG-2112819
• AMG2112819
• BIIB 024
• BIIB-024
• BIIB024
• DAY101
• MLN 2480
• MLN-2480
• MLN2480
• TAK 580
• TAK580

Definition

A 1,3-thiazolecarboxamide that is 2-[(1R)-1-aminoethyl]-1,3-thiazole-5-carboxylic acid in which the carboxy group undergoes formal condensation with the amino group of 5-chloro-4-(trifluoromethyl)pyridin-2-amine and in which the amino group undergoes formal condensation with the carboxy group of 6-amino-5-chloropyrimidine-4-carboxylic acid. It is a pan-RAF kinase inhibitor which is currently in clinical development for the treatment of radiographically recurrent or progressive low-grade glioma in children and young adults.

References

• CAS:1096708-71-2
• Chemspider:28637796
• DrugBank:DB15266
• LINCS:LSM-45644
• PDBeChem:QOP
• PMCID:PMC6012010
• PMCID:PMC7715228
• PMCID:PMC7715396
• PMID:27768280
• PMID:28082416
• PMID:30622172
• PMID:32588846
• PMID:33216827
• Patent:US20090036419

Ontology

ChEBI  ( EBI )