(E)-2-[[[4-(2-chlorophenyl)-1,3-thiazol-2-yl]hydrazinylidene]methyl]benzoic acid

Term ID

CHEBI:167669

Synonyms

2-[(E)-{2-[4-(2-chlorophenyl)-1,3-thiazol-2-yl]hydrazinylidene}methyl]benzoic acid
S312

Definition

A member of the class of 1,3-thiazoles that is 1,3-thiazole substituted by (2E)-2-(2-carboxybenzylidene)hydrazinyl and 2-chlorophenyl groups at positions 2 and 4, respectively. It is a potent inhibitor of human dihydroorotate dehydrogenase (hDHODH) with IC50 of 32 nM. It exhibits antineoplastic activity and broad-spectrum antiviral activity against various RNA viruses including influenza A, Zika, Ebola, and SARS-CoV-2 viruses.

References

PDBeChem:3X2
PMID:32754890

Ontology

ChEBI ( EBI )

Relationships

is a type of: 1,3-thiazoles benzoic acids hydrazone monochlorobenzenes

1,3-thiazoles benzoic acids hydrazone monochlorobenzenes Show first 5 Terms
has_role: anticoronaviral agent antineoplastic agent antiviral agent apoptosis inducer EC 1.3.5.2 [dihydroorotate dehydrogenase (quinone)] inhibitor

anticoronaviral agent antineoplastic agent antiviral agent apoptosis inducer EC 1.3.5.2 [dihydroorotate dehydrogenase (quinone)] inhibitor Show first 5 Terms

Phenotype

Phenotype resulting from (E)-2-[[[4-(2-chlorophenyl)-1,3-thiazol-2-yl]hydrazinylidene]methyl]benzoic acid

Phenotype where environments contain (E)-2-[[[4-(2-chlorophenyl)-1,3-thiazol-2-yl]hydrazinylidene]methyl]benzoic acid

Phenotype modified by environments containing (E)-2-[[[4-(2-chlorophenyl)-1,3-thiazol-2-yl]hydrazinylidene]methyl]benzoic acid

Human Disease Model