CHIR-98014

Term ID

CHEBI:167657

Synonyms

6-N-[2-[[4-(2,4-dichlorophenyl)-5-imidazol-1-ylpyrimidin-2-yl]amino]ethyl]-3-nitropyridine-2,6-diamine
CHIR 98014
CHIR98014
N(6)-(2-{[4-(2,4-dichlorophenyl)-5-(1H-imidazol-1-yl)pyrimidin-2-yl]amino}ethyl)-3-nitropyridine-2,6-diamine
N-6-[2-[[4-(2,4-dichlorophenyl)-5-(1H-imidazol-1-yl)-2-pyrimidinyl]amino]ethyl]-3-nitro-2,6-pyridinediamine

Definition

A member of the class of aminopyrimidines that is pyrimidine substituted by {2-[(6-amino-5-nitropyridin-2-yl)amino]ethyl}amino, 2,4-dichlorophenyl, and 1H-imidazol-1-yl groups at positions 2, 4 and 5, respectively. It is a potent ATP-competitive inhibitor of GSK3alpha and GSK3beta (IC50 values of 0.65 and 0.58 nM, respectively).

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: aminopyrimidine C-nitro compound diaminopyridine dichlorobenzene imidazoles ... Show All 6 Terms

aminopyrimidine C-nitro compound diaminopyridine dichlorobenzene imidazoles secondary amino compound Show first 5 Terms
has_role: antineoplastic agent apoptosis inducer EC 2.7.11.26 (tau-protein kinase) inhibitor hypoglycemic agent tau aggregation inhibitor ... Show All 6 Terms

antineoplastic agent apoptosis inducer EC 2.7.11.26 (tau-protein kinase) inhibitor hypoglycemic agent tau aggregation inhibitor Wnt signalling activator Show first 5 Terms

Phenotype

Phenotype resulting from CHIR-98014

Phenotype where environments contain CHIR-98014

Phenotype modified by environments containing CHIR-98014

Human Disease Model