AZD3463

Term ID

CHEBI:167653

Synonyms

AZD 3463
AZD-3463
N-[4-(4-amino-1-piperidinyl)-2-methoxyphenyl]-5-chloro-4-(1H-indol-3-yl)-2-pyrimidinamine
N-[4-(4-aminopiperidin-1-yl)-2-methoxyphenyl]-5-chloro-4-(1H-indol-3-yl)pyrimidin-2-amine

Definition

A member of the class of indoles that is 1H-indole substituted by a 2-[4-(4-aminopiperidin-1-yl)-2-methoxyanilino]-5-chloropyrimidin-4-yl group at position 3. It is an orally bioavailable dual inhibitor of ALK and IGF1R with Ki value of 0.75 nM for ALK.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: aminopiperidine aminopyrimidine indoles monomethoxybenzene organochlorine compound ... Show All 7 Terms

aminopiperidine aminopyrimidine indoles monomethoxybenzene organochlorine compound secondary amino compound tertiary amino compound Show first 5 Terms
has_role: antineoplastic agent apoptosis inducer autophagy inducer EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor

antineoplastic agent apoptosis inducer autophagy inducer EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor Show first 5 Terms

Phenotype

Phenotype resulting from AZD3463

Phenotype where environments contain AZD3463

Phenotype modified by environments containing AZD3463

Human Disease Model