JTE-607 free base

Term ID

CHEBI:167630

Synonyms

ethyl (2S)-2-{3,5-dichloro-2-hydroxy-4-[2-(4-methylpiperazin-1-yl)ethoxy]benzamido}-3-phenylpropanoate
ethyl N-{3,5-dichloro-2-hydroxy-4-[2-(4-methylpiperazin-1-yl)ethoxy]benzoyl}-L-phenylalaninate
JTE-607 (free base)
N-[3,5-dichloro-2-hydroxy-4-[2-(4-methyl-1-piperazinyl)ethoxy]benzoyl]-L-phenylalanine ethyl ester

Definition

A secondary carboxamide resulting from the formal condensation of the carboxy group of 3,5-dichloro-2-hydroxy-4-[2-(4-methylpiperazin-1-yl)ethoxy]benzoic acid with the amino group of ethyl L-phenylalaninate. It inhibits cytokine production in human peripheral blood mononuclear cells (PBMC's) without causing immunosuppression.

References

CAS:188791-71-1
Chemspider:8114170
PMID:10493164
PMID:15044056
PMID:15280441

Ontology

ChEBI ( EBI )

Relationships

is a type of: aromatic ether benzamides dichlorobenzene ethyl ester L-phenylalanine derivative ... Show All 8 Terms

aromatic ether benzamides dichlorobenzene ethyl ester L-phenylalanine derivative N-methylpiperazine phenols secondary carboxamide Show first 5 Terms
has_role: anti-inflammatory agent antineoplastic agent apoptosis inducer CPSF3 inhibitor prodrug

anti-inflammatory agent antineoplastic agent apoptosis inducer CPSF3 inhibitor prodrug Show first 5 Terms
inverse is_conjugate_acid_of: JTE-607(2+)

JTE-607(2+) Show first 5 Terms
inverse is_tautomer_of: JTE-607 zwitterion

JTE-607 zwitterion Show first 5 Terms
is_conjugate_base_of: JTE-607(2+)

JTE-607(2+) Show first 5 Terms
is_tautomer_of: JTE-607 zwitterion

JTE-607 zwitterion Show first 5 Terms

Phenotype

Phenotype resulting from JTE-607 free base

Phenotype where environments contain JTE-607 free base

Phenotype modified by environments containing JTE-607 free base

Human Disease Model