JTE-607 dihydrochloride

Term ID

CHEBI:167629

Synonyms

(-)-ethyl-N-[3,5-dichloro-2-hydroxy-4-[2-(4-methylpiperazin-1-yl)ethoxy]benzoyl]-L-phenylalaninate dihydrochloride
ethyl (2S)-2-{3,5-dichloro-2-hydroxy-4-[2-(4-methylpiperazin-1-yl)ethoxy]benzamido}-3-phenylpropanoate dihydrochloride
ethyl N-{3,5-dichloro-2-hydroxy-4-[2-(4-methylpiperazin-1-yl)ethoxy]benzoyl}-L-phenylalaninate dihydrochloride
JTE 607
JTE 607 dihydrochloride
JTE-607
JTE-607 .2HCl
JTE-607 dihydrochloride
N-[3,5-dichloro-2-hydroxy-4-[2-(4-methyl-1-piperazinyl)ethoxy]benzoyl]-L-phenylalanine ethyl ester dihydrochloride

Definition

The dihydrochloride salt of JTE-607. It is a cytokine inhibitor which suppresses the production of proinflammatory cytokines such as interleukin (IL-1beta), IL-6, IL-8, granulocyte macrophage colony stimulating factor (GM-CSF), and tumor necrosis factor (TNF-alpha). It acts as a pro-drug which is cleaved by carboxylesterase 1 (CES1) to its active free acid form, which then binds to cleavage and polyadenylation specificity factor 3 (CPSF3).

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: hydrochloride

hydrochloride Show first 5 Terms
has_part: JTE-607(2+)

JTE-607(2+) Show first 5 Terms
has_role: anti-inflammatory agent antineoplastic agent apoptosis inducer cardioprotective agent CPSF3 inhibitor ... Show All 6 Terms

anti-inflammatory agent antineoplastic agent apoptosis inducer cardioprotective agent CPSF3 inhibitor prodrug Show first 5 Terms

Phenotype

Phenotype resulting from JTE-607 dihydrochloride

Phenotype where environments contain JTE-607 dihydrochloride

Phenotype modified by environments containing JTE-607 dihydrochloride

Human Disease Model