MLN-4760

Term ID

CHEBI:166834

Synonyms

• (S,S)-2-(1-carboxy-2-(3-(3,5-dichlorobenzyl)-3H-imidazol-4-yl)-ethylamino)-4-methylpentanoic acid
• 2(S)-(1(S)-carboxy-2-(3-(3,5-dichlorobenzyl)-3H-imidazol-4-yl)-ethylamino)-4-methylpentanoic acid
• GL-1001
• GL1001
• MLN4760
• N-[(1S)-1-carboxy-3-methylbutyl]-3-(3,5-dichlorobenzyl)-L-histidine
• N-[(1S)-1-carboxy-3-methylbutyl]-3-[(3,5-dichlorophenyl)methyl]-L-histidine
• ORE-1001
• ORE-1001 free acid
• ORE1001

Definition

A L-histidine derivative that is L-histidine in which a hydrogen of the primary amino group is substituted by a (1S)-1-carboxy-3-methylbutyl group and the ring NH group is substituted by a 3,5-dichlorobenzyl group. It is a potent and selective human angiotensin-converting enzyme 2 (ACE2) inhibitor (IC50 = 0.44 nM) which was in clinical development for the treatment of ulcerative colitis.

References

• CAS:305335-31-3
• Chemspider:395128
• DrugBank:DB12271
• LINCS:LSM-45511
• PDBeChem:XX5
• PMID:14754895
• PMID:18243695
• PMID:18324760
• PMID:18356558
• PMID:19517214
• PMID:26851370
• PMID:27302421
• PMID:30806090
• PMID:31356776
• PMID:31393582
• PMID:32368013
• PMID:32866470
• PMID:33122196

Ontology

ChEBI  ( EBI )