5-[[3-(1-phenylethoxy)-4-(2-phenylethoxy)phenyl]methylene]-4-oxo-2-thioxo-3-thiazolidineacetic acid

Term ID

CHEBI:156434

Synonyms

[(5Z)-4-oxo-5-{[3-(1-phenylethoxy)-4-(2-phenylethoxy)phenyl]methylidene}-2-sulfanylidene-1,3-thiazolidin-3-yl]acetic acid
OGT2468
R3A-5a
{(5Z)-4-oxo-5-[3-(1-phenylethoxy)-4-(2-phenylethoxy)benzylidene]-2-sulfanylidene-1,3-thiazolidin-3-yl}acetic acid

Definition

A member of the class of thiazolidinones that is 2-sulfanylidene-1,3-thiazolidin-4-one in which the hydrogens at positions 3 and 5 are replaced by carboxymethyl and 3-(1-phenylethoxy)-4-(2-phenylethoxy)benzylidene groups, respectively. It is an inhibitor of protein mannosyl transferase 1 (PMT1) and blocks protein O-mannosylation.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: aromatic ether monocarboxylic acid thiazolidinone

aromatic ether monocarboxylic acid thiazolidinone Show first 5 Terms
has_role: antifungal agent EC 2.4.1.109 (dolichyl-phosphate-mannose-protein mannosyltransferase) inhibitor

antifungal agent EC 2.4.1.109 (dolichyl-phosphate-mannose-protein mannosyltransferase) inhibitor Show first 5 Terms

Phenotype

Phenotype resulting from 5-[[3-(1-phenylethoxy)-4-(2-phenylethoxy)phenyl]methylene]-4-oxo-2-thioxo-3-thiazolidineacetic acid

Phenotype where environments contain 5-[[3-(1-phenylethoxy)-4-(2-phenylethoxy)phenyl]methylene]-4-oxo-2-thioxo-3-thiazolidineacetic acid

Phenotype modified by environments containing 5-[[3-(1-phenylethoxy)-4-(2-phenylethoxy)phenyl]methylene]-4-oxo-2-thioxo-3-thiazolidineacetic acid

Human Disease Model