tilivalline

Term ID

CHEBI:156292

Synonyms

(11S,11aS)-9-hydroxy-11-(1H-indol-3-yl)-1,2,3,10,11,11a-hexahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one
(7S,8S)-11-hydroxy-8-(1H-indol-3-yl)-3,9-diazatricyclo[8.4.0.0(3,7)]tetradeca-1(10),11,13-trien-2-one
epitilivalline

Definition

A pyrrolobenzodiazepine that is (11aS)-2,3,5,10,11,11a-hexahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine substituted by an oxo group at position 5, by a hydroxy group at position 9, and by a 1H-indol-3-yl group at position 11S. It is a natural product discovered in Klebsiella oxytoca which is the causative toxin in antibiotic associated hemorrhagic colitis. It exhibits a microtubule-stabilizing activity that leads to mitotic arrest in the host cells.

References

Ontology

ChEBI ( EBI )

Resources

CTD

Relationships

is a type of: indole alkaloid indoles phenols pyrrolobenzodiazepine

indole alkaloid indoles phenols pyrrolobenzodiazepine Show first 5 Terms
has_role: bacterial metabolite microtubule-stabilising agent toxin

bacterial metabolite microtubule-stabilising agent toxin Show first 5 Terms

Phenotype

Phenotype resulting from tilivalline

Phenotype where environments contain tilivalline

Phenotype modified by environments containing tilivalline

Human Disease / Model Data