decanoyl-L-Arg-L-Val-L-Lys-L-Arg-chloromethylketone

Term ID

CHEBI:156289

Synonyms

dec-RVKR-cmk
decanoyl-Arg-Val-Lys-Arg-chloromethylketone
decanoyl-RVKR-CMK
N(2)-(1-oxodecyl)-L-arginyl-L-valyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-(2-chloroacetyl)butyl]-L-lysinamide
N(2)-decanoyl-L-arginyl-L-valyl-N-[(3S)-6-carbamimidamido-1-chloro-2-oxohexan-3-yl]-L-lysinamide

Definition

A tetrapeptide consisting of N-decanoyl-L-arginine, L-valine, L-lysine, and L-arginine joined in sequence by peptide linkages and in which the carboxy group at the C-terminus is substituted by a chloroacetyl group. It is a furin inhibitor that has antiviral activity against Chikungunya virus, Zika virus and Japanese encephalitis virus.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: organochlorine compound tetrapeptide

organochlorine compound tetrapeptide Show first 5 Terms
has_role: antiviral agent EC 3.4.21.75 (furin) inhibitor peptidomimetic

antiviral agent EC 3.4.21.75 (furin) inhibitor peptidomimetic Show first 5 Terms

Phenotype

Phenotype resulting from decanoyl-L-Arg-L-Val-L-Lys-L-Arg-chloromethylketone

Phenotype where environments contain decanoyl-L-Arg-L-Val-L-Lys-L-Arg-chloromethylketone

Phenotype modified by environments containing decanoyl-L-Arg-L-Val-L-Lys-L-Arg-chloromethylketone

Human Disease Model