CX-5461

Term ID

CHEBI:156287

Synonyms

2-(4-methyl-1,4-diazepan-1-yl)-N-[(5-methylpyrazin-2-yl)methyl]-5-oxo-5H-[1,3]benzothiazolo[3,2-a][1,8]naphthyridine-6-carboxamide
2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-N-[(5-methyl-2-pyrazinyl)methyl]-5-oxo-5H-benzothiazolo[3,2-a][1,8]naphthyridine-6-carboxamide
CX 5461
CX5461

Definition

An organic heterotetracyclic compound that is 5-oxo-5H-[1,3]benzothiazolo[3,2-a][1,8]naphthyridine-6-carboxylic acid substituted by a 4-methyl-1,4-diazepan-1-yl group at position 2 and in which the carboxy group at position 6 is substituted by a [(5-methylpyrazin-2-yl)methyl]nitrilo group. An inhibitor of ribosomal RNA (rRNA) synthesis which specifically inhibits RNA polymerase I-driven transcription of rRNA in several cancer cell lines. It is currently in phase I/II clinical trials for advanced hematologic malignancies and triple-negative breast cancer with BRCA1/2 mutation.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: diazepine naphthyridine derivative organic heterotetracyclic compound pyrazines secondary carboxamide

diazepine naphthyridine derivative organic heterotetracyclic compound pyrazines secondary carboxamide Show first 5 Terms
has_role: antineoplastic agent apoptosis inducer EC 2.7.7.6 (RNA polymerase) inhibitor

antineoplastic agent apoptosis inducer EC 2.7.7.6 (RNA polymerase) inhibitor Show first 5 Terms

Phenotype

Phenotype resulting from CX-5461

Phenotype where environments contain CX-5461

Phenotype modified by environments containing CX-5461

Human Disease Model