enrasentan

Term ID

CHEBI:156258

Synonyms

(1S,2R,3S)-1-(1,3-benzodioxol-5-yl)-3-[2-(2-hydroxyethoxy)-4-methoxyphenyl]-5-propoxy-2,3-dihydro-1H-indene-2-carboxylic acid
(1S,2R,3S)-3-(2-(2-hydroxyethoxy)-4-methoxyphenyl)-1-(3,4-(methylenedioxy)phenyl)-5-propoxy-2-indancarboxylic acid
enrasentan
enrasentanum
SB 217242
SB-217242
SB217242

Definition

A member of the class of indanes that is 2,3-dihydro-1H-indene which is substituted by a 1,3-benzodioxol-5-yl group, carboxy group, 2-(2-hydroxyethoxy)-4-methoxyphenyl group and a propoxy group at positions 1S, 2R, 3S and 5, respectively. It is an orally active mixed endothelin A/B receptor antagonist with a 100-fold greater affinity for the endothelin A receptor. The drug was being developed by GSK for the treatment of congestive heart failure and pulmonary hypertension (clinical trials discontinued).

References

Ontology

ChEBI ( EBI )

Resources

CTD

Relationships

is a type of: aromatic ether benzodioxoles indanes monocarboxylic acid monomethoxybenzene ... Show All 6 Terms

aromatic ether benzodioxoles indanes monocarboxylic acid monomethoxybenzene primary alcohol Show first 5 Terms
has_role: antihypertensive agent endothelin receptor antagonist

antihypertensive agent endothelin receptor antagonist Show first 5 Terms

Phenotype

Phenotype resulting from enrasentan

Phenotype where environments contain enrasentan

Phenotype modified by environments containing enrasentan

Human Disease Model