AMG-925

Term ID

CHEBI:145537

Synonyms

2-hydroxy-1-[2-({9-[(1r,4r)-4-methylcyclohexyl]-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl}amino)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]ethan-1-one
2-hydroxy-1-[2-{[9-(trans-4-methylcyclohexyl)-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl]amino}-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]ethanone
AMG 925
AMG-925
AMG925
FLX 925
FLX-925
FLX925

Definition

An organic heterotricyclic compound that is 9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidine which is substituted by a [6-(hydroxyacetyl)-5,6,7,8-tetrahydro-1,6-naphthyridin-2-yl]nitrilo group at position 2 and by a trans-4-methylcyclohexyl group at position 9. It is a FLT3 and CDK4 dual kinase inhibitor that has antineoplastic activity. Currently under clinical investigation in patients with relapsed or refractory acute myeloid leukemia (AML).

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: naphthyridine derivative organic heterotricyclic compound primary alpha-hydroxy ketone secondary amino compound tertiary amino compound

naphthyridine derivative organic heterotricyclic compound primary alpha-hydroxy ketone secondary amino compound tertiary amino compound Show first 5 Terms
has_role: antineoplastic agent apoptosis inducer EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor EC 2.7.11.22 (cyclin-dependent kinase) inhibitor

antineoplastic agent apoptosis inducer EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor EC 2.7.11.22 (cyclin-dependent kinase) inhibitor Show first 5 Terms

Phenotype

Phenotype resulting from AMG-925

Phenotype where environments contain AMG-925

Phenotype modified by environments containing AMG-925

Human Disease Model