Search Ontology:
ChEBI
ivosidenib
- Term ID
- CHEBI:145430
- Synonyms
-
- (2S)-N-{(1S)-1-(2-chlorophenyl)-2-[(3,3-difluorocyclobutyl)amino]-2-oxoethyl}-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide
- AG-120
- ivosidenib
- ivosidenibum
- N-{(1S)-1-(2-chlorophenyl)-2-[(3,3-difluorocyclobutyl)amino]-2-oxoethyl}-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxo-L-prolinamide
- Tibsovo
- Definition
- A tertiary carboxamide resulting from the formal condensation of the carboxy group of (2S)-1-(4-cyanopyridin-2-yl)-5-oxopyrrolidine-2-carboxylic acid with the secondary amino group of (2S)-2-(2-chlorophenyl)-N-(3,3-difluorocyclobutyl)-2-[(5-fluoropyridin-3-yl)amino]acetamide. It is approved by the FDA for the treatment of acute myeloid leukemia (AML) in patients with an isocitrate dehydrogenase-1 (IDH1) mutation.
- References
-
- CAS:1448347-49-6
- DrugBank:DB14568
- KEGG:D11090
- PMCID:PMC6217633
- PMID:27245312
- PMID:29670690
- PMID:29860938
- PMID:29925981
- PMID:29934313
- PMID:30093505
- PMID:30209701
- PMID:30222290
- PMID:30231226
- PMID:30260154
- PMID:30260155
- PMID:30610623
- PMID:30692099
- PMID:30758648
- PMID:30822797
- PMID:31011758
- PMID:31028664
- PMID:31300360
- PMID:31382862
- Wikipedia:Ivosidenib
- Ontology
- ChEBI ( EBI )
- is a type of
- has_role
-
Show All 6 Terms
Show first 5 Terms
Phenotype
Phenotype resulting from ivosidenib
Phenotype where environments contain ivosidenib
Phenotype modified by environments containing ivosidenib
Human Disease Model