andrastin D

Term ID

CHEBI:142874

Synonyms

methyl (5beta,8alpha,9beta,10alpha,13alpha)-15-hydroxy-4,4,8,12,16-pentamethyl-3,17-dioxoandrosta-11,15-diene-14-carboxylate
methyl 15-hydroxy-4,4,8alpha,12,16-pentamethyl-3,17-dioxo-5beta,9beta,10alpha,13alpha-androsta-11,15-diene-14-carboxylate

Definition

A 3-oxo steroid that is andrastin C in which the acetoxy group at the 3beta position has undergone formal oxidative cleavage to afford the corresponding 3-oxo derivative. A farnesyltransferase inhibitor produced by Penicillium roqueforti, a filamentous fungus involved in the ripening of several kinds of blue cheeses.

References

CAS:184432-08-4
KNApSAcK:C00016286
PMID:15826038
PMID:9031675

Ontology

ChEBI ( EBI )

Relationships

is a type of: 3-oxo steroid 5beta steroid 15-hydroxy steroid 17-oxo steroid enol ... Show All 7 Terms

3-oxo steroid 5beta steroid 15-hydroxy steroid 17-oxo steroid enol meroterpenoid methyl ester Show first 5 Terms
has_role: EC 2.5.1.58 (protein farnesyltransferase) inhibitor Penicillium metabolite

EC 2.5.1.58 (protein farnesyltransferase) inhibitor Penicillium metabolite Show first 5 Terms
inverse has_functional_parent: andrastin E andrastin F

andrastin E andrastin F Show first 5 Terms
inverse is_conjugate_base_of: andrastin D(1-)

andrastin D(1-) Show first 5 Terms
is_conjugate_acid_of: andrastin D(1-)

andrastin D(1-) Show first 5 Terms

Phenotype

Phenotype resulting from andrastin D

Phenotype where environments contain andrastin D

Phenotype modified by environments containing andrastin D

Human Disease Model