6beta-hydroxycortisone

Term ID

CHEBI:139269

Synonyms

6beta,17,21-trihydroxypregn-4-ene-3,11,20-trione
6beta-17alpha,21-trihydroxypregn-4-ene-3,11,20-trione
6beta-hydroxycortisone

Definition

A C21-steroid that is cortisone bearing an additional hydroxy substituent at the 6beta-position. It is produced as a metabolite of cortisol by cytochrome p450-3A4 (CYP3A4, an important enzyme involved in the metabolism of a variety of exogenous and endogenous compounds) and can be used to detect moderate and potent CYP3A4 inhibition in vivo.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: 3-oxo-Delta(4) steroid 6beta-hydroxy steroid 11-oxo steroid 17alpha-hydroxy steroid 20-oxo steroid ... Show All 9 Terms

3-oxo-Delta(4) steroid 6beta-hydroxy steroid 11-oxo steroid 17alpha-hydroxy steroid 20-oxo steroid 21-hydroxy steroid C21-steroid primary alpha-hydroxy ketone tertiary alpha-hydroxy ketone Show first 5 Terms
has_functional_parent: cortisone

cortisone Show first 5 Terms
has_role: human metabolite probe

human metabolite probe Show first 5 Terms

Phenotype

Phenotype resulting from 6beta-hydroxycortisone

Phenotype where environments contain 6beta-hydroxycortisone

Phenotype modified by environments containing 6beta-hydroxycortisone

Human Disease / Model Data