bis(7)-tacrine

Term ID

CHEBI:138435

Synonyms

B7T
bis(7)-tetrahydroaminacrine
heptylene-bis(tacrine)
N,N'-bis(1,2,3,4-tetrahydro-9-acridinyl)-1,7-heptanediamine
N,N'-di(1,2,3,4-tetrahydroacridin-9-yl)heptane-1,7-diamine

Definition

A secondary amino compound consisting of two molecules of tacrine that are linked together through their exocyclic amino groups by a heptane-1,7-diyl chain. Bis(7)-tacrine is an acetylcholinesterase (AChE)inhibitor (IC50 0.40 nM, >1,000 times more potent than tacrine). It has also been found to protect against H2O2 -induced apoptosis in rat pheochromocytoma cells.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: secondary amino compound

secondary amino compound Show first 5 Terms
has_functional_parent: tacrine

tacrine Show first 5 Terms
has_role: apoptosis inhibitor EC 1.14.13.39 (nitric oxide synthase) inhibitor EC 3.1.1.7 (acetylcholinesterase) inhibitor neuroprotective agent

apoptosis inhibitor EC 1.14.13.39 (nitric oxide synthase) inhibitor EC 3.1.1.7 (acetylcholinesterase) inhibitor neuroprotective agent Show first 5 Terms

Phenotype

Phenotype resulting from bis(7)-tacrine

Phenotype where environments contain bis(7)-tacrine

Phenotype modified by environments containing bis(7)-tacrine

Human Disease Model