demoxytocin

Term ID

CHEBI:135900

Synonyms

• 1-(3-mercaptopropionic acid)-oxytocin
• 1-{[(4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-[(2S)-butan-2-yl]-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl]carbonyl}-L-prolyl-L-leucylglycinamide
• deaminooxytocin
• demoxitocina
• demoxytocin
• demoxytocine
• demoxytocinum
• desamino oxytocin
• desamino-oxytocin
• desaminooxytocin
• ODA 914
• ODA-914
• Odeax
• Sandopart
• Sandopral

Definition

A heterodetic cyclic peptide that is the synthetic analog of the peptide hormone oxytocin where the free amino group in the half-cystine residue is replaced by hydrogen. The mechanism of action and pharmacological properties of demoxytocin and oxytocin are similar. The drug affects the permeability of the cell membrane, increasing the content of calcium ions in smooth muscle cells, thereby increasing its contraction. It stimulates the contraction of smooth muscles of the uterus, as well as stimulating the contraction of myoepithelial cells of the mammary gland, and enhances the secretion of milk.

References

• CAS:113-78-0
• Chemspider:395815
• DrugBank:DB13798
• Drug_Central:3126
• KEGG:D07228
• PMID:29309759
• PMID:393119
• PMID:428195
• PMID:4446103
• PMID:445976
• PMID:468056
• PMID:4740061
• PMID:4887636
• PMID:5020079
• PMID:5081052
• PMID:5152525
• PMID:5303864
• PMID:530450
• PMID:5470650
• PMID:5487933
• PMID:5498369
• PMID:5537710
• PMID:555036
• PMID:5561292
• PMID:5678655
• PMID:5756152
• PMID:5756153
• PMID:6575575
• PMID:6575576
• PMID:700921
• PMID:7460491
• PMID:756601
• PMID:7650072
• PMID:9083475
• PMID:940106
• Wikipedia:Demoxytocin

Ontology

ChEBI  ( EBI )