clodronic acid

Term ID

CHEBI:110423

Synonyms

• (Dichloro-phosphono-methyl)-phosphonic acid
• (dichloromethanediyl)bis(phosphonic acid)
• (dichloromethylene)bisphosphonic acid
• (dichloromethylene)diphosphonic acid
• acide clodronique
• acido clodronico
• acidum clodronicum
• clodronate
• clodronic acid
• clodronsaeure
• dichloromethylene-1,1-bisphosphonic acid
• dichloromethylene-1,1-diphosphonic acid
• dichloromethylidene diphosphonate

Definition

An organochlorine compound that is methylene chloride in which both hydrogens are replaced by phosphonic acid groups. It inhibits bone resorption and soft tissue calcification, and is used (often as the disodium salt tetrahydrate) as an adjunct in the treatment of severe hypercalcaemia associated with malignancy, and in the management of osteolytic lesions and bone pain associated with skeletal metastases.

References

• Beilstein:1876367
• CAS:10596-23-3
• DrugBank:DB00720
• Drug_Central:690
• KEGG:D03545
• LINCS:LSM-5802
• PMID:15658873
• PMID:7818726
• PMID:8421279
• Patent:BE672205

Ontology

ChEBI  ( EBI )

Resources

CTD