nalidixic acid

Term ID

CHEBI:100147

Synonyms

• 1,4-dihydro-1-ethyl-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid
• 1-Aethyl-7-methyl-1,8-naphthyridin-4-on-3-karbonsaeure
• 1-ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid
• 1-ethyl-7-methyl-1,4-dihydro-1,8-naphthyridin-4-one-3-carboxylic acid
• 1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
• 1-Ethyl-7-methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid
• 3-carboxy-1-ethyl-7-methyl-1,8-naphthyridin-4-one
• acide nalidixique
• acido nalidixico
• acidum nalidixicum
• nalidixic acid

Definition

A monocarboxylic acid comprising 1,8-naphthyridin-4-one substituted by carboxylic acid, ethyl and methyl groups at positions 3, 1, and 7, respectively. An orally administered antibacterial, it is used in the treatment of lower urinary-tract infections due to Gram-negative bacteria, including the majority of E. coli, Enterobacter, Klebsiella, and Proteus species.

References

• CAS:389-08-2
• DrugBank:DB00779
• Drug_Central:1875
• KEGG:C05079
• KEGG:D00183
• LINCS:LSM-5590
• PDBeChem:NIX
• PMID:11321869
• PMID:12002106
• PMID:12399485
• PMID:12702698
• PMID:14107587
• PMID:16107187
• PMID:16423473
• PMID:16667857
• PMID:16803589
• PMID:17132068
• PMID:17631104
• PMID:18788798
• PMID:19071706
• PMID:28166217
• Patent:BE612258
• Patent:US3590036
• Reaxys:750515
• VSDB:1880
• Wikipedia:Nalidixic_Acid

Ontology

ChEBI  ( EBI )

Resources

CTD