| Term: | pancreas D cell |
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| Note: | This page represents a term created by the combination ("post-composition") of two ontology terms. For more information on the individual terms, click the hyperlinked name. |
| Name: | pancreas |
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| Synonyms: | |
| Definition: | The pancreas is an organ composed of endocrine and exocrine glandular tissue that produce hormones and digestive enzymes. Unlike in other studied vertebrates the pancreas in zebrafish develops from two buds, one anterior and one posterior. In adult fish the main pancreas is located on the right side attached to the lateral aspect of the intestine by the pancreatic duct. Typically, one large islet and 3-6 smaller islets occupy the main pancreas. The tail of the pancreas is embedded with single beta cells or clusters of small islets and extends caudally along the right side of the intestine. |
| Ontology: | Anatomy Ontology [ZFA:0000140] |
| Name: | D cell |
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| Synonyms: | D cells |
| Definition: | A cell found throughout the gastrointestinal tract and in the pancreas. They secrete somatostatin in both an endocrine and paracrine manner. Somatostatin inhibits gastrin, cholecystokinin, insulin, glucagon, pancreatic enzymes, and gastric hydrochloric acid. A variety of substances which inhibit gastric acid secretion (vasoactive intestinal peptide, calcitonin gene-related peptide, cholecystokinin, beta-adrenergic agonists, and gastric inhibitory peptide) are thought to act by releasing somatostatin. |
| Ontology: | Anatomy Ontology [ZFA:0009228] |