ZFIN Post-Composed Term: pharyngeal arch IRE1-mediated unfolded protein response

Term:	pharyngeal arch IRE1-mediated unfolded protein response
Note:	This page represents a term created by the combination ("post-composition") of two ontology terms. For more information on the individual terms, click the hyperlinked name.

Name:	pharyngeal arch
Synonyms:	pharyngeal arches
Definition:	One of a series of paired bony or cartilaginous arches that develop along the lateral walls of the foregut. The pharyngeal arches have developmental contributions from endoderm, mesoderm, and neural crest cells and are separated by anterior lateral endoderm out-pockets known as pharyngeal pouches. There are seven pharyngeal arches.
Ontology:	Anatomy Ontology [ZFA:0001306]

Name:	IRE1-mediated unfolded protein response
Synonyms:	endoplasmic reticulum unfolded protein response; IRE1 signaling, ERN1-mediated unfolded protein response, inositol-requiring enzyme 1-mediated unfolded protein response, inositol-requiring transmembrane kinase/endonuclease signal transduction, IRE1 branch of UPR, IRE1 signal transduction pathway, IRE1 signaling in response to endoplasmic reticulum stress, IRE1alpha unfolded protein response, IRE1p unfolded protein response, UPR signaling by IRE1 stress sensor
Definition:	The series of molecular signals mediated by the endoplasmic reticulum stress sensor IRE1 (Inositol-requiring transmembrane kinase/endonuclease). Begins with activation of IRE1 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. One target of activated IRE1 is the transcription factor HAC1 in yeast, or XBP1 in mammals; IRE1 cleaves an intron of a mRNA coding for HAC1/XBP1 to generate an activated HAC1/XBP1 transcription factor, which controls the up regulation of UPR-related genes. At least in mammals, IRE1 can also signal through additional intracellular pathways including JNK and NF-kappaB.
Ontology:	GO: Biological Process [GO:0036498] QuickGO AmiGO