| Term: | testis site of double-strand break |
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| Note: | This page represents a term created by the combination ("post-composition") of two ontology terms. For more information on the individual terms, click the hyperlinked name. |
| Name: | testis |
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| Synonyms: | testes |
| Definition: | Male reproductive organ. Adult zebrafish testes are paired organs forming elongated structures, internally organized into tubules. These tubules are formed by seminiferous epithelium containing cysts of spermatogonia and spermatocytes surrounded by somatic support cells, called Sertoli cells. Cysts are arranged around a lumen containing spermatozoa that is connected to the efferent ducts. The interstitial regions between the tubules contain the steroid-producing Leydig cells, connective tissue, and blood vessels. |
| Ontology: | Anatomy Ontology [ZFA:0000598] |
| Name: | site of double-strand break |
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| Synonyms: | DNA damage foci, DNA damage focus, ionizing radiation-induced foci, IRIF, site of DSB |
| Definition: | A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix. |
| Ontology: | GO: Cellular Component [GO:0035861] QuickGO AmiGO |