| Term: | macrophage tumor necrosis factor-mediated signaling pathway |
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| Note: | This page represents a term created by the combination ("post-composition") of two ontology terms. For more information on the individual terms, click the hyperlinked name. |
| Name: | macrophage |
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| Synonyms: | histiocyte |
| Definition: | A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells. |
| Ontology: | Anatomy Ontology [ZFA:0009141] |
| Name: | tumor necrosis factor-mediated signaling pathway |
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| Synonyms: | adipocytokine signaling pathway, TNF-alpha-mediated signaling pathway, tumor necrosis factor alpha-mediated signaling pathway, tumor necrosis factor-mediated signalling pathway |
| Definition: | The series of molecular signals initiated by tumor necrosis factor binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| Ontology: | GO: Biological Process [GO:0033209] QuickGO AmiGO |