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Phenotype Figure Summary
Marker:
sphk2
Conditions:
Standard or Control
Publication
Data
Fish
Anatomy
Park
et al.
, 2019
Fig. 5
sphk2
wcm2/wcm2
(AB/TU)
whole organism
asah1a
expression increased amount, abnormal
whole organism
asah2
expression decreased amount, abnormal
Mendelson
et al.
, 2017
Fig. 1
sphk2
wcm2/wcm2
epiboly delayed, abnormal
whole organism sphingosine 1-phosphate decreased amount, abnormal
whole organism sphingosine increased amount, abnormal
Fig. 2
sphk2
wcm2/wcm2
epiboly delayed, abnormal
gastrulation delayed, abnormal
heart tube increased amount, abnormal
Fig. 4
sphk2
wcm2/wcm2
whole organism
cers2b
expression increased amount, abnormal
Fig. 7
sphk2
wcm2/wcm2
oocyte
cers2b
expression increased amount, abnormal
oocyte sphingoid 1-phosphate absent, abnormal
oocyte sphingosine increased amount, abnormal
Hisano
et al.
, 2015
Fig. 10
sphk2
ko822/ko822
ventral mandibular arch disorganized, abnormal
Fig. 3
sphk2
ko822/ko822
, 
sphk2
ko822/ko822
heart duplicated, abnormal
heart morphogenesis process quality, abnormal
heart shape, abnormal
heart split bilaterally, abnormal
Fig. 5
sphk2
ko822/ko822
, 
sphk2
ko822/+
+ MO1-sphk2
heart duplicated, abnormal
heart morphogenesis process quality, abnormal
heart shape, abnormal
heart split bilaterally, abnormal
Fig. 9
sphk2
ko822/ko822
median fin blistered, abnormal
Mendelson
et al.
, 2015
Fig. 3
sphk2
wcm2/wcm2
, 
sphk2
wcm2/wcm2
cell migration to the midline involved in heart development decreased occurrence, abnormal
embryonic heart tube formation decreased occurrence, abnormal
heart edematous, abnormal
heart tube split bilaterally, abnormal
post-vent region epithelium blistered, abnormal
Fig. 4
sphk2
wcm2/wcm2
cell migration to the midline involved in heart development decreased occurrence, abnormal
embryonic heart tube formation decreased occurrence, abnormal
heart tube split bilaterally, abnormal
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