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Phenotype Figure Summary
Marker:
rpgrip1
Conditions:
Standard or Control
Publication
Data
Fish
Anatomy
Li
et al.
, 2021
Figure 1
rpgrip1
fh314/fh314
retinal cone cell degenerate, abnormal
retinal rod cell degenerate, abnormal
Figure 2
rpgrip1
fh314/fh314
green sensitive photoreceptor cell zpr-1 labeling decreased amount, abnormal
red sensitive photoreceptor cell zpr-1 labeling decreased amount, abnormal
Figure 3
rpgrip1
fh314/fh314
retinal cone cell apoptotic process increased occurrence, abnormal
retinal cone cell apoptotic, abnormal
Figure 4
rpgrip1
fh314/fh314
eye
cat
expression decreased amount, abnormal
eye
gclm
expression decreased amount, abnormal
eye
gpx1a
expression decreased amount, abnormal
eye
nfe2l2a
expression decreased amount, abnormal
eye
nqo1
expression decreased amount, abnormal
eye
sod1
expression decreased amount, abnormal
eye
sod2
expression decreased amount, abnormal
eye reactive oxygen species increased amount, abnormal
Figure 5
rpgrip1
fh314/fh314
eye catalase activity decreased occurrence, abnormal
eye glutathione decreased amount, abnormal
eye malonaldehyde increased amount, abnormal
eye superoxide dismutase activity decreased occurrence, abnormal
Figure 6
rpgrip1
fh314/fh314
eye
il1b
expression increased amount, abnormal
eye
il6
expression increased amount, abnormal
eye
mprip
expression increased amount, abnormal
eye
tnfa
expression increased amount, abnormal
Alhasani
et al.
, 2020
Fig. 1
rpgrip1
fh314/fh314
retinal photoreceptor layer decreased thickness, abnormal
Fig. 2
rpgrip1
fh314/fh314
retinal rod cell
rho
expression decreased amount, abnormal
Fig. 3
rpgrip1
fh314/fh314
retinal outer nuclear layer photoreceptor cell apoptotic, abnormal
Fig. 4
rpgrip1
fh314/fh314
eye
cat
expression decreased amount, abnormal
eye
gclm
expression decreased amount, abnormal
eye
gpx1a
expression decreased amount, abnormal
eye
nqo1
expression decreased amount, abnormal
eye
sod1
expression decreased amount, abnormal
eye
sod2
expression decreased amount, abnormal
eye reactive oxygen species increased amount, abnormal
Fig. 5
rpgrip1
fh314/fh314
eye catalase activity decreased occurrence, abnormal
eye glutathione decreased amount, abnormal
eye malonaldehyde increased amount, abnormal
eye superoxide dismutase activity decreased occurrence, abnormal
Fig. 6
rpgrip1
fh314/fh314
eye
atf4a
expression increased amount, abnormal
eye
atf6
expression increased amount, abnormal
eye
blp
expression increased amount, abnormal
eye
xbp1
expression increased amount, abnormal
Fig. 7
rpgrip1
fh314/fh314
eye
il1b
expression increased amount, abnormal
eye
il6
expression increased amount, abnormal
eye
tnfa
expression increased amount, abnormal
Raghupathy
et al.
, 2017
Fig. 2
rpgrip1
fh314/fh314
retinal outer nuclear layer
rho
expression mislocalised, abnormal
retinal rod cell cell body
rho
expression mislocalised, abnormal
retinal rod cell development decreased process quality, abnormal
retinal rod cell lacks all parts of type retinal rod cell photoreceptor outer segment, abnormal
retinal rod cell photoreceptor cell cilium decreased length, abnormal
retinal rod cell photoreceptor cell outer segment organization decreased process quality, abnormal
retinal rod cell photoreceptor inner segment
rho
expression mislocalised, abnormal
Fig. 3
rpgrip1
fh314/fh314
retinal cone cell absence due to degeneration, abnormal
retinal photoreceptor layer has fewer parts of type retinal cone cell, abnormal
retinal photoreceptor layer has fewer parts of type retinal rod cell, abnormal
retinal rod cell absence due to degeneration, abnormal
Fig. 4
rpgrip1
fh314/fh314
retinal outer nuclear layer apoptotic process increased occurrence, abnormal
Fig. 5
rpgrip1
fh314/fh314
retinal cone cell disorganized, abnormal
retinal photoreceptor layer has fewer parts of type retinal cone cell, abnormal
Fig. 6
rpgrip1
fh314/fh314
retinal cone cell cell body
opn1lw1
expression mislocalised, abnormal
retinal cone cell cell body
opn1mw1
expression mislocalised, abnormal
retinal cone cell cell body
opn1sw1
expression mislocalised, abnormal
retinal cone cell retinal cone cell development decreased process quality, abnormal
retinal cone cell synapse
opn1lw1
expression mislocalised, abnormal
retinal cone cell synapse
opn1mw1
expression mislocalised, abnormal
retinal cone cell synapse
opn1sw1
expression mislocalised, abnormal
Fig. 7
rpgrip1
fh314/fh314
detection of light stimulus involved in visual perception decreased process quality, abnormal
melanocyte melanosome mislocalised, abnormal
Fig. 8
rpgrip1
fh314/fh314
eye photoreceptor cell ciliary base Ab2-rab8a labeling decreased amount, abnormal
eye photoreceptor cell photoreceptor outer segment Ab2-rab8a labeling absent, abnormal
retinal cone cell photoreceptor inner segment Ab2-rab8a labeling mislocalised, abnormal
retinal cone cell photoreceptor outer segment Ab2-grk1 labeling decreased amount, abnormal
retinal rod cell photoreceptor inner segment Ab2-grk1 labeling mislocalised, abnormal
retinal rod cell photoreceptor inner segment Ab5-gnat1 labeling mislocalised, abnormal
Fig. S6
rpgrip1
fh314/fh314
retinal cone cell photoreceptor inner segment ab1-rpgr labeling mislocalised, abnormal
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