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Phenotype Figure Summary
Marker:
hsf4
Conditions:
Standard or Control
Publication
Data
Fish
Anatomy
Cui
et al.
, 2021
Fig. 7
hsf4
hzu5/hzu5
lens
cdkn1a
expression increased amount, abnormal
lens
cxcl12a
expression increased amount, abnormal
lens
il15
expression increased amount, abnormal
lens
mif
expression increased amount, abnormal
lens epithelium cellular senescence increased process quality, abnormal
lens epithelium senescent, abnormal
lens opaque, abnormal
Morishita
et al.
, 2021
Fig. 3
jt13Tg + CRISPR1-hsf4
, 
RW + CRISPR1-hsf4
lens central region has extra parts of type lens fiber cell lysosome, abnormal
lens fiber cell differentiation decreased process quality, abnormal
lens fiber cell organelle disassembly decreased process quality, abnormal
Zhang
et al.
, 2020
Fig. 5
hsf4
hzu5/hzu5
(AB)
lens
dnase1l1l
expression absent, abnormal
lens enucleation decreased process quality, abnormal
lens fiber cell differentiation process quality, abnormal
lens nucleated, abnormal
Fig. 6
hsf4
hzu5/hzu5
(AB)
lens enucleation decreased process quality, abnormal
lens fiber cell differentiation process quality, abnormal
lens nucleated, abnormal
Cui
et al.
, 2019
Fig. 6
hsf4
hzu5/hzu5
lens
cryaba
expression decreased amount, abnormal
maintenance of lens transparency disrupted, abnormal
Gao
et al.
, 2017
Fig. 1
hsf4
hzu5/hzu5
(AB)
whole organism
hsf4
expression absent, abnormal
Fig. 2
hsf4
hzu5/hzu5
(AB)
lens fiber cell differentiation disrupted, abnormal
lens fiber cell nucleus present, abnormal
lens opaque, abnormal
Fig. 3
hsf4
hzu5/hzu5
(AB)
lens fiber cell differentiation disrupted, abnormal
lens fiber cell early endosome present, abnormal
lens fiber cell late endosome mislocalised, abnormal
lens fiber cell late endosome present, abnormal
lens fiber cell nucleus present, abnormal
lens fiber cell organelle present, abnormal
Fig. 4
hsf4
hzu5/hzu5
(AB)
lens fiber cell disorganized, abnormal
lens fiber cell increased amount, abnormal
Fig. 7
hsf4
hzu5/hzu5
(AB)
lens
tp53
expression decreased amount, abnormal
lens cysteine-type endopeptidase activator activity involved in apoptotic process decreased process quality, abnormal
lens fiber cell differentiation disrupted, abnormal
lens fiber cell nucleus present, abnormal
Fig. S2
hsf4
hzu5/hzu5
(AB)
lens epithelium epithelial cell increased amount, abnormal
Cui
et al.
, 2013
Fig. 5
WT + MO1-hsf4
lens fiber cell differentiation decreased process quality, abnormal
lens nucleate quality, abnormal
Fig. 6
WT + MO1-hsf4
positive regulation of deoxyribonuclease activity decreased process quality, abnormal
Cui
et al.
, 2012
Fig. 6
WT + MO1-hsf4
lens chromatin damaged, abnormal
lens nucleate quality, abnormal
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