Publication	Data		Fish	Anatomy
Grdseloff et al., 2023	Figure 1		ccm2m201/m201	heart aldh1a2 expression increased distribution, abnormal heart aldh1a2 expression mislocalised, abnormal
Lazzaroni et al., 2023	Table S3		ccm2m201/m201	heart angpt2b expression increased amount, abnormal heart cdcp1a expression increased amount, abnormal heart robo4 expression increased amount, abnormal heart thbs1b expression decreased amount, abnormal heart thbs2b expression decreased amount, abnormal heart thbs3a expression decreased amount, abnormal heart thbs3b expression decreased amount, abnormal heart vcam1b expression decreased amount, abnormal
Yang et al., 2023	Figure 5		twu34Tg + MO1-ccm2	heart dilated, abnormal
Li et al., 2021	Figure 1		sd2Tg; y1Tg + CRISPR1-ccm2 + CRISPR2-ccm2 + CRISPR3-ccm2 + CRISPR4-ccm2	blood circulation decreased process quality, abnormal caudal vein plexus dilated, abnormal caudal vein plexus structure, cavities, abnormal cranial blood vessel dilated, abnormal heart dilated, abnormal nucleate erythrocyte accumulation caudal vein plexus, abnormal
	Figure 1 - figure supplement 2		sd2Tg; y1Tg + CRISPR1-ccm2 + CRISPR2-ccm2 + CRISPR3-ccm2 + CRISPR4-ccm2	heart dilated, abnormal subintestinal vein increased branchiness, abnormal
	Figure 2		sd2Tg; y1Tg + CRISPR1-ccm2 + CRISPR2-ccm2 + CRISPR3-ccm2 + CRISPR4-ccm2	caudal vein plexus anatomical surface irregularly shaped, abnormal caudal vein plexus dilated, abnormal caudal vein plexus lumen obstructed, abnormal caudal vein plexus structure, cavities, abnormal intussusceptive angiogenesis arrested, abnormal nucleate erythrocyte accumulation caudal vein plexus, abnormal
	Figure 3 - figure supplement 1		y1Tg + MO1-ccm2 ,   ccm2m201/m201	heart dilated, abnormal
	Figure 4		y1Tg + CRISPR1-ccm2 + CRISPR2-ccm2 + CRISPR3-ccm2 + CRISPR4-ccm2 ,   ig11Tg; is5Tg + CRISPR1-ccm2 + CRISPR2-ccm2 + CRISPR3-ccm2 + CRISPR4-ccm2	caudal vein plexus dilated, abnormal developmental vascular plexus endothelial cell EGFP expression increased amount, abnormal developmental vascular plexus endothelial cell EGFP expression spatial pattern, abnormal
	Figure 5		y1Tg + CRISPR1-ccm2 + CRISPR2-ccm2 + CRISPR3-ccm2 + CRISPR4-ccm2	caudal vein plexus dilated, abnormal heart dilated, abnormal
	Figure 6		y1Tg + CRISPR1-ccm2 + CRISPR2-ccm2 + CRISPR3-ccm2 + CRISPR4-ccm2 ,   y1Tg + CRISPR1-ccm2 + CRISPR2-ccm2 + CRISPR3-ccm2 + CRISPR4-ccm2 + MO1-ccm2	caudal vein plexus dilated, abnormal heart dilated, abnormal
	Figure 7		y1Tg + CRISPR1-ccm2 + CRISPR2-ccm2 + CRISPR3-ccm2 + CRISPR4-ccm2	brain anatomical surface lesioned, abnormal brain hemorrhagic, abnormal brain vasculature dilated, abnormal brain vasculature morphology, abnormal brainstem morphology, abnormal cerebellum brain vasculature morphology, abnormal forebrain brain vasculature morphology, abnormal nucleate erythrocyte accumulation brain vasculature, abnormal spinal cord morphology, abnormal
	Figure 7 - figure supplement 2		y1Tg + CRISPR1-ccm2 + CRISPR2-ccm2 + CRISPR3-ccm2 + CRISPR4-ccm2	caudal vein plexus structure, cavities, abnormal
Li et al., 2020	Fig. 1		sd2Tg; y1Tg + CRISPR1-ccm2 + CRISPR2-ccm2 + CRISPR3-ccm2 + CRISPR4-ccm2	caudal vein plexus dorsal side dilated, abnormal caudal vein plexus folded, abnormal caudal vein plexus ventral side absent, abnormal heart dilated, abnormal
	Fig. 2		sd2Tg; y1Tg + CRISPR1-ccm2 + CRISPR2-ccm2 + CRISPR3-ccm2 + CRISPR4-ccm2	caudal vein plexus dorsal side dilated, abnormal caudal vein plexus folded, abnormal caudal vein plexus ventral side absent, abnormal
Choi et al., 2018	Fig. S5		twu34Tg + MO1-ccm2	heart dilated, abnormal
Donat et al., 2018	Fig. 4		ccm2m201/m201; s940Tg	atrioventricular canal endocardium Notch signaling involved in heart development increased occurrence, abnormal atrioventricular canal endocardium Venus expression increased distribution, abnormal atrioventricular valve morphogenesis decreased process quality, abnormal ventricular endocardium Notch signaling involved in heart development increased occurrence, abnormal ventricular endocardium Venus expression increased distribution, abnormal
Otten et al., 2018	Fig. 1		ccm2m201/m201; s843Tg	heart dilated, abnormal
	Fig. 4		ccm2m201/m201; s843Tg	heart dilated, abnormal whole organism klf2a expression increased amount, abnormal
Renz et al., 2015	Fig. 2		ccm2m201/m201; s843Tg	endocardial cushion absent, abnormal endocardium proliferative, abnormal heart edematous, abnormal lateral dorsal aorta endothelial cell increased amount, abnormal subintestinal vein increased branchiness, abnormal
	Fig. 4		ccm2m201/m201; s843Tg	endocardial cushion absent, abnormal
	Fig. 5		ccm2m201/m201; twu34Tg	heart edematous, abnormal heart increased size, abnormal
	Fig. 6		ccm2m201/m201; s843Tg	endocardial cushion absent, abnormal endocardium proliferative, abnormal heart edematous, abnormal lateral dorsal aorta endothelial cell increased amount, abnormal
Zhou et al., 2015	Fig. 4		ccm2hi296aTg/hi296aTg ,   ccm2hi296aTg/hi296aTg; p150Tg	cardiac jelly absent, abnormal heart increased size, abnormal myocardium decreased thickness, abnormal
	Fig. 6		ccm2hi296aTg/hi296aTg; p150Tg	heart increased size, abnormal
Yoruk et al., 2012	Fig. 1		ccm2s259/s259; twu34Tg	heart dilated, abnormal
Zheng et al., 2010	Fig. 2		p150Tg + MO1-ccm2 ,   ccm2hi296aTg	heart dilated, abnormal myocardium decreased thickness, abnormal
	Fig. 4		ccm2hi296aTg	heart dilated, abnormal myocardium decreased thickness, abnormal
Kleaveland et al., 2009	Fig. 4		ccm2hi296aTg/hi296aTg; y1Tg ,   y1Tg + MO1-ccm2	blood vasculature obstructed, abnormal heart dilated, abnormal heart edematous, abnormal
	Fig. S8		WT + MO1-ccm2	blood vessel endothelial cell cell-cell junction decreased length, abnormal
Mariappan et al., 2009	Fig. 2		WT + MO4-ccm2	heart increased size, abnormal
	text only		WT + MO4-ccm2	blood circulation disrupted, abnormal
Milan et al., 2009	text only		ccm2hi296aTg	atrium dilated, abnormal cardiac ventricle dilated, abnormal
Hogan et al., 2008	Fig. 2		ccm2hi296aTg/hi296aTg ,   ccm2hi296aTg/hi296aTg; y1Tg	caudal vein dilated, abnormal caudal vein morphology, abnormal heart dilated, abnormal pericardium edematous, abnormal primordial midbrain channel dilated, abnormal trunk vasculature dilated, abnormal
Sakaguchi et al., 2008	Fig. 5		ccm2s259/s259; s843Tg	liver morphology, abnormal
Jin et al., 2007	text only		ccm2s259/s259 (TL)	blood vessel morphogenesis disrupted, abnormal common cardinal vein decreased size, abnormal
Malone et al., 2007	Fig. 4		WT + MO2-ccm2	aortic arch constricted, abnormal blood circulation decreased rate, abnormal pericardium edematous, abnormal
	Fig. S2		WT + MO2-ccm2	blood circulation decreased rate, abnormal
	text only		WT + MO2-ccm2 ,   WT + MO3-ccm2	aortic arch constricted, abnormal blood circulation decreased rate, abnormal pericardium edematous, abnormal
Phenotype Annotation (1994-2006)	Fig. for (hi296a)		ccm2hi296aTg	gut quality, abnormal heart quality, abnormal liver quality, abnormal pharyngeal arch 3-7 skeleton quality, abnormal
	Fig. for (m201)		ccm2m201/m201 (AB)	anatomical system quality, abnormal heart quality, abnormal
	Fig. for (s259)		ccm2s259	heart quality, abnormal
Amsterdam et al., 2004	text only		ccm2hi296aTg/hi296aTg	atrium increased size, abnormal eye decreased size, abnormal gut hypoplastic, abnormal head decreased size, abnormal heart increased accumulation blood, abnormal liver hypoplastic, abnormal mandibular arch skeleton increased thickness, abnormal pericardium edematous, abnormal yolk edematous, abnormal yolk grey, abnormal yolk swollen, abnormal
Serluca et al., 2002	Fig. 1		ccm2m201	blood circulation arrested, abnormal heart contraction decreased magnitude, abnormal pronephric glomerulus unfused from pronephric glomerulus, abnormal
Stainier et al., 1996	Fig. 1		ccm2m201/m201 (AB)	heart increased size, abnormal myocardium distended, abnormal