| ZFIN ID: ZDB-EXP-240327-8 |
Experiment Conditions Description: chemical treatment by environment: tivozanib
| chemical treatment by environment: tivozanib |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | tivozanib |
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| Synonyms: | 1-[2-chloro-4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-3-(5-methyl-3-isoxazolyl)urea, 1-{2-chloro-4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-3-(5-methyl-1,2-oxazol-3-yl)urea, AV 951, AV-951, AV951, Kil 8951, KIL-8951, KRN 951, KRN-951, KRN951, N-[2-chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl]-N'-(5-methyl-3-isoxazolyl)urea, tivozanib, tivozanibum |
| Definition: | A member of the class of quinolines that is 6,7-dimethoxyquinoline substituted by a 3-chloro-4-{[(5-methyl-1,2-oxazol-3-yl)carbamoyl]amino}phenoxy group at position 4. It is a potent and selective inhibitor of VEGF receptor tyrosine kinases and was previously in clinical development for the treatment of metastatic renal cell carcinoma. |
| Ontology: | ChEBI [CHEBI:91327] ( EBI ) |
| Publication: | Fetsko et al., 2022 |
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