| ZFIN ID: ZDB-EXP-231201-5 |
Experiment Conditions Description: biological treatment: Cryptococcus neoformans, chemical treatment by environment: GI254023X
| biological treatment: Cryptococcus neoformans |
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| Name: | biological treatment |
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| Synonyms: | |
| Definition: | Experimental condition in which the organism is treated with a microorganism. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000105] |
| Name: | Cryptococcus neoformans |
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| Synonyms: | Blastomyces neoformans, Debaryomyces neoformans, Filobasidiella neoformans, Lipomyces neoformans, Saccharomyces neoformans, Torula neoformans, Torulopsis neoformans |
| Definition: | |
| Ontology: | Taxonomy for ZECO [NCBITaxon:5207] |
| chemical treatment by environment: GI254023X |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | GI254023X |
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| Synonyms: | (2R)-N-[(1S)-2,2-dimethyl-1-[(methylamino)carbonyl]-propyl]-2-[(1S)-1-[formyl(hydroxy)amino]ethyl]-5-phenylpentanamide, (2R,3S)-3-(formyl-hydroxyamino)-2-(3-phenyl-1-propyl)butanoic acid [(1S)-2,2-dimethyl-1-methylcarbamoyl-1-propyl]amide, GI-254023X, GI-4023, GI4023, N(2)-[(2R)-2-{(1S)-1-[formyl(hydroxy)amino]ethyl}-5-phenylpentanoyl]-N,3-dimethyl-L-valinamide |
| Definition: | A L-valine derivative that is 3-methyl-L-valine in which carboxy OH group is replaced by a methylnitrilo group and the one of the amino hydrogens is replaced by a (2R)-2-{(1S)-1-[formyl(hydroxy)amino]ethyl}-5-phenylpentanoyl group. It is a potent MMP9 and ADAM10 metalloprotease inhibitor with IC50 of 2.5 and 5.3 nM, respectively. |
| Ontology: | ChEBI [CHEBI:143102] ( EBI ) |
| Publication: | Gibson et al., 2022 |
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