| ZFIN ID: ZDB-EXP-231107-6 |
Experiment Conditions Description: transection: caudal fin, chemical treatment by environment: atropine, chemical treatment by environment: numidargistat
| transection: caudal fin |
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| Name: | transection |
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| Synonyms: | |
| Definition: | Cutting transversly of an organ or tissue. Type of cutting often used to divide the spinal cord to investigate neural regeneration in zebrafish. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000181] |
| Name: | caudal fin |
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| Synonyms: | tail, tail fin |
| Definition: | Fin that is the most posterior median fin. It is composed of a complex of three modified centra and modified neural and hemal arches and spines. |
| Ontology: | Anatomy Ontology [ZFA:0001058] |
| chemical treatment by environment: atropine |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | atropine |
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| Synonyms: | (+,-)-tropyl tropate, (+-)-atropine, (+-)-hyoscyamine, (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl tropate, 8-methyl-8-azabicyclo[3.2.1]oct-3-yl 3-hydroxy-2-phenylpropanoate, 8-methyl-8-azabicyclo[3.2.1]oct-3-yl tropate, [(1S,5R)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl] 3-hydroxy-2-phenyl-propanoate, Atropin, atropina, Atropine, dl-Hyoscyamine, dl-tropyltropate, rac-(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl 3-hydroxy-2-phenylpropanoate, rac-tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate, tropine tropate |
| Definition: | A racemate composed of equimolar concentrations of (S)- and (R)-atropine . It is obtained from deadly nightshade (Atropa belladonna) and other plants of the family Solanaceae. |
| Ontology: | ChEBI [CHEBI:16684] ( EBI ) |
| chemical treatment by environment: numidargistat |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | numidargistat |
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| Synonyms: | (3R,4S)-1-L-alanyl-3-amino-4-(3-boronopropyl)pyrrolidine-3-carboxylic acid, (3R,4S)-3-amino-1-[(2S)-2-aminopropanoyl]-4-(3-boronopropyl)pyrrolidine-3-carboxylic acid, CB 1158, CB-1158, CB1158, INCB 001158, INCB-001158, INCB001158, numidargistat, numidargistatum |
| Definition: | An aminopyrrolidine that is pyrrolidine substituted by (2S)-2-aminopropanoyl, amino, carboxy, and 3-boronopropyl groups at positions 1, 3, 3, and 4 (the 3R,4S-stereoisomer). It is a selective arginase inhibitor being developed by Calithera Biosciences for the treatment of solid tumours. |
| Ontology: | ChEBI [CHEBI:195556] ( EBI ) |
| Publication: | Chen et al., 2022 |
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