| ZFIN ID: ZDB-EXP-230831-16 |
Experiment Conditions Description: chemical treatment by environment: AS1842856, chemical treatment by environment: loperamide
| chemical treatment by environment: AS1842856 |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | AS1842856 |
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| Synonyms: | 5-amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid, 5-amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, AS 1842856, AS-1842856, FOXO1 inhibitor |
| Definition: | A quinolone that is 4-quinolone substituted at positions 1, 3, 5, 6 and 7 by ethyl, carboxy, amino, fluorine, and cyclohexylamino groups, respectively. It can directly bind to and block the transcription activity of the active forkhead box protein O1 (Foxo1), but not the Ser256-phosphorylated form. It induces cell death and growth arrest in Burkitt lymphoma cell lines at low concentrations. |
| Ontology: | ChEBI [CHEBI:145800] ( EBI ) |
| chemical treatment by environment: loperamide |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | loperamide |
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| Synonyms: | 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide, loperamida, loperamide, loperamidum |
| Definition: | A synthetic piperidine derivative, effective against diarrhoea resulting from gastroenteritis or inflammatory bowel disease. |
| Ontology: | ChEBI [CHEBI:6532] ( EBI ) |
| Publication: | Casteels et al., 2021 |
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